We’re breaking down the Detroit Lions schedule, odds, and predictions for the 2025 NFL season following the official schedule release. The Lions are projected to win 10.5 games across our best sports betting sites, and we’re offering our 2025 win-loss predictions with AI picks for all 17 games.
📅 Detroit Lions 2025 schedule & odds for every game
Odds via DraftKings as of Thursday, May 15. All times listed in Eastern Time.
| Week | Date | Opponent | Favorite |
|---|---|---|---|
| 1 | Sunday, Sept. 7 @ 4:25 PM | at Packers | Packers -1.5 |
| 2 | Sunday, Sept. 14 @ 1 PM | vs. Bears | Lions -4.5 |
| 3 | Monday, Sept. 22 @ 8:15 PM | at Ravens | Ravens -3.5 |
| 4 | Sunday, Sept. 28 @ 1 PM | vs. Browns | Lions -10.5 |
| 5 | Sunday, Oct. 5 @ 4:25 PM | at Bengals | Lions -1.5 |
| 6 | Sunday, Oct. 12 @ 8:20 PM | at Chiefs | Chiefs -3 |
| 7 | Monday, Oct. 20 @ 7 PM | vs. Buccaneers | Lions -3.5 |
| 8 | BYE WEEK | – | – |
| 9 | Sunday, Nov. 2 @ 1 PM | vs. Vikings | Lions -4.5 |
| 10 | Sunday, Nov. 9 @ 4:25 PM | at Commanders | Commanders -1.5 |
| 11 | Sunday, Nov. 16 @ 8:20 PM | at Eagles | Eagles -3.5 |
| 12 | Sunday, Nov. 23 @ 1 PM | vs. Giants | Lions -8.5 |
| 13 | Thursday, Nov. 27 @ 1 PM | vs. Packers | Lions -2.5 |
| 14 | Thursday, Dec. 4 @ 8:15 PM | vs. Cowboys | Lions -6 |
| 15 | Sunday, Dec. 14 @ 4:25 PM | at Rams | Lions -1.5 |
| 16 | Sunday, Dec. 21 @ 4:25 PM | vs. Steelers | Lions -6 |
| 17 | Thursday, Dec. 25 @ 4:30 PM | at Vikings | Lions -2.5 |
| 18 | TBD | at Bears | Lions -1.5Detroit Lions 2025 predictions: Game-by-game picks & final recordCheck out our 2025 NFL season predictions for projected standings, playoff results, and award winners – and a breakdown of how our AI model predicts every game. 🤖 Detroit Lions 2025 AI projections
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